The S.S. Ramona, a tramp steamer registered from Panama, was the ship captained by Allan Thompson that Tintin, Captain Haddock and Piotr Skut boarded after being shipwrecked in The Red Sea Sharks. The ship was carrying many refugees, or slaves, from Africa and was unsuccessfully scuttled by Allan with all on board. Haddock then assumed command of the ship after it was abandoned by Allan and his crew. Afterwards, the refugees agreed to help sail the ship to neutral Djibouti.

The ship was then attacked by a U-boat sent by Roberto Rastapopoulos, but the Ramona was then aided by the USS Los Angeles. The submarine's crew made one last attempt to destroy the Ramona by attaching a limpet mine to the boat beside the explosives store, but this failed as the diver carrying the mine was hit by the ship's anchor. A shark swallowed the mine and swam away, causing the shark to blow up and causing confusion to all the characters hours later.

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